EXERCISE EFFECTS ON MUSCLE GLUCOSE UPTAKE AND INSULIN ACTION A search for intracellular signalling pathways
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Exercise Causes Muscle GLUT4 Translocation in an Insulin-Independent Manner
Glucose uptake in skeletal muscle is dependent on the translocation of GLUT4 glucose transporters to the plasma membrane. The most important stimulators of glucose transport in skeletal muscle are insulin and exercise. Glucose uptake in skeletal muscle during exercise induces acceleration of many processes compared to the resting state. The scientific literature does not underline the role play...
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Exercise increases the rate of glucose uptake into the contracting skeletal muscles. This effect of exercise is similar to the action of insulin on glucose uptake, and the mechanism through which both stimuli increase skeletal muscle glucose uptake involves the translocation of GLUT-4 glucose transporters to the plasma membrane and transverse tubules. Most studies suggest that exercise and insu...
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The signaling mechanisms by which exercise improves muscle insulin AMPKa is not a sensitive method to judge AMPK activation. So, 172 sensitivity seem even harder to solve than to get people to exercise. Exercise (muscle contraction) has two diverse effects on muscle glucose metabolism. Firstly, acute exercise stimulates glucose uptake in skeletal muscles via translocation of GLUT4 translocation...
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Type II diabetes is characterized by defects in insulin action on peripheral tissues, such as skeletal muscle, adipose tissue and liver and pancreatic beta-cell defects. Since the skeletal muscle accounts for approx. 75% of whole body insulin-stimulated glucose uptake, defects in this tissue play a major role in the impaired glucose homoeostasis in Type II diabetic patients. Thus identifying de...
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Chronic inflammation is involved in the pathogenesis of insulin resistance, atherosclerosis, neurodegeneration, and tumour growth. Regular exercise offers protection against type 2 diabetes, cardiovascular diseases, colon cancer, breast cancer, and dementia. Evidence suggests that the protective effect of exercise may to some extent be ascribed to the antiinflammatory effect of regular exercise...
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تاریخ انتشار 2005